The Oxford Handbook of Acute Medicine. Ramrakha P. & Moore K.P.  1997

The Oxford Handbook of Acute Medicine.  Ramrakha P. & Moore K.P.  2004

The Oxford Handbook of Acute Medicine.  Ramrakha P., Moore K.P. & Sam A.  2010

This ~870 page handbook is part of a popular handbook series in Medicine. It covers all aspects of Acute Medicine.  It has been highly successful and has sold over 100 000 copies.


Peer Reviewed Publications

 Frequency of acute pancreatitis in fulminant hepatic failure using isoenzyme markers. Ede R, Moore K.P., Marshall WJ and Williams R.  Gut 1988; 29: 778-781.

Leukotriene C4 elimination and metabolism in man. Maltby N, Taylor GW, Ritter J, Moore K.P., Fuller R and Dollery CT. Journal of Allergy and Clinical Immunology 1990; 85: 3-9.

Single total paracentesis for tense ascites: Sequential hemodynamic changes and right atrial size. Panos M, Moore K.P., Vlavianos P, Chambers J, Anderson J, Gimson AES, Slater JDH, Rees LH, Westaby D and Williams R.   Hepatology 1990; 11: 662-667.

Increased production of cysteinyl-leukotrienes in hepatorenal syndrome. Moore K.P., Taylor G, Maltby N, Siegers D, Fuller R, Dollery CT, and Williams R. Journal of Hepatology 1990; 11: 263-271.

Renal and extra-renal production of prostacyclin and thromboxane in decompensated liver disease and hepatorenal syndrome. Moore K.P., Ward P, Taylor G.W., and Williams R.   Gastroenterology 1991; 100: 1069-1077.

Plasma Immunoreactive endothelin in hepatorenal syndrome and liver disease. Moore K.P., J Wendon, M Frazer, J Karani, R Williams, and K.F Badr. New England Journal of Medicine 1992: 327: 1774-1779.

Expression of the human neuropeptide tyrosine (NPY) Y1 receptor.  J Wharton, L Gordon, J Byrne, H Herzog, L Selbie, Moore K.P., M Sullivan, M Elder, G Moscoso, K Taylor, J Shine, and J Polak. Proceedings of the National Academy of Sciences 1993: 90: 687-691.

Marked overproduction of non-cyclooxygenase derived F2-isoprostanes in the hepatorenal syndrome.  Morrow JD., Moore K.P., Awad J., Badr KF., Williams R. Roberts LJ. Journal of Lipid Mediators; 1993: 6:417-20.

Identification of the major urinary metabolite of the F2-isoprostane 8-isoprostaglandin F2a in humans. Roberts L.J, Moore K.P., Zackert W, and Morrow J. D. Journal of Biological Chemistry 1996: 271; 34: 20617-20620

N-Acetylcysteine prevents development of the hyperdynamic circulation in the portal hypertensive rat. B. Fernando, R. Marley, S. Holt, R. Anand, D. Harry, P. Sanderson, R. Smith, G. Hamilton, and K. P. Moore. Hepatology 1998: 28: 689-94.

A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis induced renal failure. Moore K.P, Holt S.G., Patel R.P Svistunenko D.A, Zackert W., Goodier D., Reeder B., Clozel M, Anand R., Cooper C.E., Morrow J.D., Wilson M.., Darley-Usmar V., and L.J. Roberts II. Journal of Biological Chemistry 1998: 273: 31731-31737.

N-Acetycytseine improves renal function in the hepatorenal syndrome. S. Holt, D. Goodier., Marley R., Patch D., Burroughs A., Fernando B., Harry D & Moore K.P., Lancet 1999: 353: 294-295.

Increased lipid peroxidation in Rhabdomyolysis. S.G Holt, Goodier D, Reeder B, Harvey S., Morrow J.D., Wilson M.T., Roberts L.J and Moore K.P. Lancet 1999: 353: 1471.

Increased sensitivity to endotoxemia in cirrhosis. Harry D., Anand R., Holt S., Marley R., Goodier D., and Moore K.P. Hepatology 1999: 30:1198-1205.

A chemiluminescense based assay for S-nitrosoalbumin and other plasma S-nitrosothiols. R. Marley, M. Feelisch, S. Holt   and Moore K.P. Free Radical Research 2000: 32: 1-9.

Change in occurrence of paracetamol overdose in UK after introduction of blister packs. Turvill JL, Burroughs AK, & Moore K.P. Lancet 2000:355: 2048-9.

Endothelial Transcytosis of Myeloperoxidase Confers Specificity to Vascular Extracellular Matrix Proteins as Targets of Tyrosine Nitration. Baldus S., Eiserich J.P., Mani A., Castro L., Figueroa M., Chumley P., Ma W., Tousson A. White R., Moore K.P., & Freeman B.A. Journal of Clinical  Investigation 2001:108:1759-1770.

The metabolic fate of dietary polyphenols in humans. Rechner A. Kuhnle G, Bremner P., Hubbard G., Moore K.P., & C. Rice-Evans. Free Radical Biology and Medicine 2002; 33 (2) 220-235.

The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans. Richardson G., Hicks S.L., Frost M.T., Moore K.P., Benjamin N., and G.M. McKnight. Nitric Oxide 2002: 7: 24-29.

The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. AR Rechner, G Kuhnle, H Hu, A Roedig-Penman, M van den Braak, Moore K.P., Rice-Evans C. Free Radical Research 2002 ;36:1229-41.

Anti-platelet activity of nitric oxide is substantially prolonged through formation of plasma S-nitrosothiols: impact of low molecular weight thiols. Crane M.S., Ollosson R., Moore K.P., Rossi A.R. & Megson I.L. Journal of Biological Chemistry 2002;277:46858-63

Discovery of new products of lipid peroxidation formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are up-regulated by increased oxygen tension. Fessel J.P, Porter N.A, Moore K.P., Sheller J.R., and L.J. Roberts. Proceedings of the National Academy of Sciences (USA) 2002;99:16713-8.

The effect of dietary nitrate on salivary, plasma and urinary nitrate metabolism in humans. A.S. Pannala, A.R. Mani, J. P. E. Spencer, V. Skinner, K. R. Bruckdorfer, K. P. Moore and C.A. Rice-Evans. Free Radical Biology and Medicine 2003; 1;34:576-84.

Mani AR, Pannala AS, Orie NN, Ollosson R, Harry D, Rice-Evans CA, Moore KP. Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine. Biochemical Journal. 2003;374:521-7.

Rechner AR, Smith MA, Kuhnle G, Gibson GR, Debnam ES, Srai SK, Moore KP, Rice-Evans CA. Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products. Free Radical Biology and Medicine. 2004;36:212-25.

Dhamrait SS, Stephens JW, Cooper JA, Acharya J, Mani AR, Moore K, Miller GJ, Humphries SE, Hurel SJ, Montgomery HE Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2. European Heart Journal. 2004;25:468-75

Martin HM, Moore KP, Bosmans E, Davies S, Burroughs AK, Dhillon AP, Tosh D, Harrison R Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liver. Free Radical Biology and Medicine. 2004;37:1214-23

Ebrahimkhani MR, Mani AR, Moore K.P Hydrogen sulphide and the hyperdynamic circulation in cirrhosis: a hypothesis. Gut. 2005 54:1668-7.

Mani AR, Ebrahimkhani MR, Ippolito S, Ollosson R, Moore KP. Metalloprotein-dependent decomposition of S-nitrosothiols: studies on the stabilization and measurement of S-nitrosothiols in tissues. Free Radical Biology and Medicine. 2006; 40:1654-63.

Pannala AS, Mani AR, Rice-Evans CA, Moore KP. pH-dependent nitration of para-hydroxyphenylacetic acid in the stomach. Free Radical Biology and Medicine. 2006; 41:896-901.

Mani AR, Ippolito S, Moreno JC, Visser TJ, Moore KP. The metabolism and dechlorination of chlorotyrosine in vivo. Journal of Biological Chemistry; 2007;282:29114-21

Kuhnle GG, Story GW, Reda T, Mani AR, Moore KP, Lunn JC, Bingham SA. Diet-induced endogenous formation of nitroso compounds in the GI tract. Free Radical Biology and Medicine. 2007;43; 1040-7.

Wong F, Moore K, Dingemanse J, Jalan R. Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndrome. Hepatology. 2008;47(1):160-8.

Stadlbauer V, Wright GA, Banaji M, Mukhopadhya A, Mookerjee RP, Moore K, Jalan R. Relationship between activation of the sympathetic nervous system and renal blood flow autoregulation in cirrhosis. Gastroenterology. 2008;134:111-9.

Mani AR, Montagnese S, Jackson CD, Jenkins CW, Head IM, Stephens RC, Moore KP, Morgan MY. Decreased heart rate variability in patients with cirrhosis relates to the presence and degree of hepatic encephalopathy. Am J Physiol Gastrointest Liver Physiol. 2009;296:G330-8.

Kumar S, Hall RJ, Mani AR, Moore KP, Camici PG, Rimoldi OE, Williams AJ, Macleod KT.

Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum. Biochemical Biophysical Research Communications. 2009; 387:77-82.

Charunwatthana P, Abul Faiz M, Ruangveerayut R, Maude RJ, Rahman MR, Roberts LJ 2nd, Moore K, Bin Yunus E, Hoque MG, Hasan MU, Lee SJ, Pukrittayakamee S, Newton PN, White NJ, Day NP, Dondorp AM. N-acetylcysteine as adjunctive treatment in severe malaria: a randomized, double-blinded placebo-controlled clinical trial. Crit Care Med. 2009;37(2):516-22

Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, Carney CK, Masterson TS, Amin T, Wright DW, Wilson MT, Oates JA, Roberts LJ Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proceedings of the National Academy of Sciences 2010; 107:2699-704.

Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ 2nd, Ischiropoulos H. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med. 2012;52(1):1-6.

Increased renal expression and urinary excretion of TLR4 in acute kidney injury associated with cirrhosis. Shah N, Mohamed FE, Jover-Cobos M, Macnaughtan J, Davies N, Moreau R, Paradis V, Moore K, Mookerjee R, Jalan R. Liver Int. 2013;33:398-409

Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. Angeli P, Gines P, Wong F, Bernardi M, Boyer TD, Gerbes A, Moreau R, Jalan R, Sarin SK, Piano S,Moore K, Lee SS, Durand F, Salerno F, Caraceni P, Kim WR, Arroyo V, Garcia-Tsao G; International Club of Ascites. Gut. 2015;64(4):531-7.

Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation. Mazza G, Rombouts K, Rennie Hall A, Urbani L, Vinh Luong T, Al-Akkad W, Longato L, Brown D, Maghsoudlou P, Dhillon AP, Fuller B, Davidson B, Moore K, Dhar D, De Coppi P, Malago M, Pinzani M. Sci Rep. 2015 Aug 7;5:13079. doi: 10.1038/srep13079

DIgital Alcohol Management ON Demand (DIAMOND) feasibility randomised controlled trial of a web-based intervention to reduce alcohol consumption in people with hazardous and harmful use versus a face-to-face intervention: protocol. Hamilton F, Hornby J, Sheringham J, Kerry S, Linke S, Solmi F, Ashton C, Moore K.P, Murray E. Pilot and Feasibility Studies 2015